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    CD1-CD247

    时时彩提前开奖作弊 www.sw4ac.com Exalpha Biologicals produces and sells products for Life Science Research, including monoclonal and polyclonal antibodies, for use in immunohistochemistry, western blot, ELISA and Flow Cytometry. We offer over 800 products and, through collaborations with other scientists as well as our own in-house R&D programs, Exalpha continues to bring leading edge products to market. Our family of CD antibodies combines quality and performance with reasonable prices to make our CD antibodies the best value in the market today. Our family of Proliferation products offer easy all-in-one kits or stand alone antibodies to quantitate proliferating cells. Take a look at our website or call us for additional information.

    Note: no information is available on CDw145, CD181, CD182, CD185-194, CD196-199, CD211, CD214-216, CD218-220, CD237

    Background

    CD: cluster designation of monoclonal antibodies (clusters of differentiation) Designated at the 1st to 7th Workshops on International Human Leukocyte Differentiation Antigens

    The last conference was in 2000. The next conference is in 2004.

    HLDA Workshops are the primary mechanism to characterize leukocyte surface antigenic molecules and epies; erythroid antigens are now included

    For 1st to 6th workshops, antibodies were submitted to the organizing laboratory, coded and sent to participating laboratories for testing against various cell types. For the 7th workshop, a CD designation could be established for a molecule if its gene has been cloned and at least one specific monoclonal antibody had been studied in the Workshop

    Interpretation should be based on cellular distribution of staining, proportion of positively stained cells, staining intensity and cutoff levels.

    CD1

    Family of non-polymorphic MHC class I-like glycoproteins

    Also member of immunoglobulin superfamily

    On chromosome 1q22-23 (not MHC linked)

    Has 5 different subsets, all noncovalently associated with 12 kd beta 2 microglobulin Function: restrict T cell responses to certain antigens; may mediate thymic T cell development

    Positive staining(normal): cortical thymocytes (70%), activated T cells, Langerhans cells, interdigitating dendritic cells

    Positive staining(disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell hi
    stiocytosis

    Positive staining(disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis

    Negative staining: mature peripheral T cells

    CD1a

    Positive staining(normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders

    Positive staining(disease): Langerhans cell histiocytosis (fairly specific), myeloid leukemias, some B cell malignancies; dendritic cells in most peripheral cutaneous T cell lymphomas, AJCP 2001;116:72

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